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Article

A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis.

PloS one - 30 Nov 2010

Xia Zongqi, Chibnik Lori B, Glanz Bonnie I, Liguori Maria, Shulman Joshua M, Tran Dong, Khoury Samia J, Chitnis Tanuja, Holyoak Todd, Weiner Howard L, Guttmann Charles R G, De Jager Philip L

Abstract excerpt

BACKGROUND: Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS). We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset Alzheimer's Disease (AD) influence brain volume and cognition in MS patie...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21152065
DOI: 10.1371/journal.pone.0014169
PMCID: PMC2994939

Genes

PCK1
CLU
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21152065-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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