Article
A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis.
PloS one - 30 Nov 2010
Xia Zongqi, Chibnik Lori B, Glanz Bonnie I, Liguori Maria, Shulman Joshua M, Tran Dong, Khoury Samia J, Chitnis Tanuja, Holyoak Todd, Weiner Howard L, Guttmann Charles R G, De Jager Philip L
Abstract excerpt
BACKGROUND: Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS). We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset Alzheimer's Disease (AD) influence brain volume and cognition in MS patients. METHODS/PRINCIPAL FINDINGS: MS subjects were genotyped for five single nucleotide polymorphisms (snps) associated...
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