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Genome-wide study of longitudinal brain imaging measures of multiple sclerosis progression across six clinical trials

31 Aug 2023

Abstract excerpt

Abstract While the genetics of MS risk susceptibility are well-described, and recent progress has been made on the genetics of disease severity, the genetics of disease progression remain elusive. We therefore investigated the genetic determinants of MS progression on longitudinal brain MRI: change in brain volume (BV) and change in T2 lesion volume (T2LV), reflecting progressive tissue loss and increasing...

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PMID: 37652990
DOI: 10.1038/s41598-023-41099-0

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