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Article

Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.

European journal of human genetics : EJHG - 1 Apr 2011

Ferreira Manuel A R, McRae Allan F, Medland Sarah E, Nyholt Dale R, Gordon Scott D, Wright Margaret J, Henders Anjali K, Madden Pamela A, Visscher Peter M, Wray Naomi R, Heath Andrew C, Montgomery Grant W, Duffy David L, Martin Nicholas G

Abstract excerpt

Genome-wide association studies followed by replication provide a powerful approach to map genetic risk factors for asthma. We sought to search for new variants associated with asthma and attempt to replicate the association with four loci reported previously (ORMDL3, PDE4D, DENND1B and IL1RL1)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21150878
DOI: 10.1038/ejhg.2010.191
PMCID: PMC3060316

Genes

ORMDL3
CXCL14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21150878-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.PMID 21150878Read ↗

Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population.Semantic proximity Read ↗

Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.Semantic proximity Read ↗

Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.Semantic proximity Read ↗

Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis.Semantic proximity Read ↗

A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.Semantic proximity Read ↗

Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.Semantic proximity Read ↗

Genome-wide association studies for discovery of genes involved in asthma.Semantic proximity Read ↗

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels.Semantic proximity Read ↗

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma.Semantic proximity Read ↗

17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom.Semantic proximity Read ↗

Genome-wide association study to identify genetic determinants of severe asthma.Semantic proximity Read ↗

Identification of deleterious and regulatory genomic variations in known asthma lociSemantic proximity Read ↗

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