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Article

ATM directs DNA damage responses and proteostasis via genetically separable pathways.

Science signaling - 9 Jan 2018

Lee Ji-Hoon, Mand Michael R, Kao Chung-Hsuan, Zhou Yi, Ryu Seung W, Richards Alicia L, Coon Joshua J, Paull Tanya T

Abstract excerpt

The protein kinase ATM is a master regulator of the DNA damage response but also responds directly to oxidative stress. Loss of ATM causes ataxia telangiectasia, a neurodegenerative disorder with pleiotropic symptoms that include cerebellar dysfunction, cancer, diabetes, and premature aging. We genetically separated the activation of ATM by DNA damage from that by oxidative stress using separation-of-function...

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Source

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Identifiers

PMID: 29317520
DOI: 10.1126/scisignal.aan5598
PMCID: PMC5898228

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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ATM directs DNA damage responses and proteostasis via genetically separable pathways.PMID 29317520Read ↗

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