Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 2012

Martin A, David V, Li H, Dai B, Feng J Q, Quarles L D

Abstract excerpt

Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the phosphaturic hormone fibroblast growth factor (FGF)-23, leading to hypophosphatemia, aberrant vitamin D metabolism, and rickets/osteomalacia. Compound mutant Phex-deficient Hyp and Dmp1(ko) mice exhibit nonadditive phenotypes, suggesting that DMP1 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcification, Physiologic
Share to Extracellular Matrix Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Familial Hypophosphatemic Rickets

Share to Fibroblast Growth Factor-23

Share to Fibroblast Growth Factors

Share to PHEX Phosphate Regulating Neutral Endopeptidase

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 22930691
DOI: 10.1210/me.2012-1062
PMCID: PMC3487625

Genes

FGF23
DMP1
PHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice.PMID 22930691Read ↗

A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice.Semantic proximity Read ↗

Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.Semantic proximity Read ↗

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice.Semantic proximity Read ↗

Mineralizing enthesopathy is a common feature of renal phosphate-wasting disorders attributed to FGF23 and is exacerbated by standard therapy in hyp mice.Semantic proximity Read ↗

DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype.Semantic proximity Read ↗

Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.Semantic proximity Read ↗

Studies of the DMP1 57-kDa Functional Domain both in vivo and in vitroSemantic proximity Read ↗

The wrickkened pathways of FGF23, MEPE and PHEX.Semantic proximity Read ↗

DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.Semantic proximity Read ↗

Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets.Semantic proximity Read ↗

Protective roles of DMP1 in high phosphate homeostasis.Semantic proximity Read ↗

Chronic inhibition of ERK1/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.