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Article

Variants of tissue-type plasminogen activator that display extraordinary resistance to inhibition by the serpin plasminogen activator inhibitor type 1.

The Journal of biological chemistry - 6 Jun 1997

Tachias K, Madison E L

Abstract excerpt

Fibrinolysis is regulated in part by the interaction of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1). Previous investigations suggest that three specific arginine residues, Arg-298, Arg-299, and Arg-304 of t-PA, play a critical role in this important regulatory interaction. Our earlier studies have demonstrated that conversion of any of these three residues to a...

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Identifiers

PMID: 9169416
DOI: 10.1074/jbc.272.23.14580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Variants of tissue-type plasminogen activator that display extraordinary resistance to inhibition by the serpin plasminogen activator inhibitor type 1.PMID 9169416Read ↗

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Converting tissue plasminogen activator to a zymogen: a regulatory triad of Asp-His-Ser.Semantic proximity Read ↗

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