Article
Minority HIV mutation detection in dried blood spots indicates high specimen integrity and reveals hidden archived drug resistance.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Feb 2011
Wei Xierong, Youngpairoj Ae S, Garrido Carolina, Zahonero Natalia, Corral Angelica, de Mendoza Carmen, Heneine Walid, Johnson Jeffrey A, Garcia-Lerma J Gerardo
Abstract excerpt
BACKGROUND: Dried blood spots (DBS) could serve as an attractive, cost-effective alternative to plasma for HIV drug resistance testing. OBJECTIVES: To assess the utility and potential gain in genotypic information with sensitive testing of DBS compared to conventional bulk plasma genotyping, and examine the correlation of majority and minority-level resistance mutations in DBS with treatment history. STUDY...
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