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Article

Impact of genetic variants on fentanyl metabolism in major breast surgery patients: a candidate gene association study.

Pharmacogenomics - 1 Jan 2024

Kumar Shathish, Ramasamy Kesavan, Natarajan Harivenkatesh, Venkatraman Shravan, Eriyat Vishnu, Kundra Pankaj

Abstract excerpt

AIM: The study aimed to examine the association of two selected candidate SNPs rs2242480 (CYP3A4) and rs1045642 (ABCB1) with metabolic ratio of plasma norfentanyl to fentanyl concentrations in patients undergoing major breast surgeries. METHODS: The retrospective cross-sectional study was done in 257 female patients. DNA extraction, genotyping of selected SNPs, and drug levels measurement were employed. RESULTS:...

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Source

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Identifiers

PMID: 39563600
DOI: 10.1080/14622416.2024.2429365
PMCID: PMC11703455

Genes

ABCB1
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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