Article
Polymorphisms in genes coding for GRK2 and GRK5 and response differences in antihypertensive-treated patients.
Pharmacogenetics and genomics - 1 Jan 2011
Lobmeyer Maximilian T, Wang Liewei, Zineh Issam, Turner Stephen T, Gums John G, Chapman Arlene B, Cooper-DeHoff Rhonda M, Beitelshees Amber L, Bailey Kent R, Boerwinkle Eric, Pepine Carl J, Johnson Julie A
Abstract excerpt
OBJECTIVES: The G-protein-coupled receptor kinases (GRKs) GRK2 and GRK5 are important regulators of β-adrenergic signaling. This study characterized single-nucleotide polymorphisms (SNPs) in the GRK2 gene (ADRBK1) and determined if these and a GRK5 Gln41Leu polymorphism affect the blood pressure (BP) response to atenolol or hydrochlorothiazide or adverse cardiovascular outcomes in hypertensives. METHODS: ADRBK1...
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