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Article

GRK5 Gln41Leu polymorphism is not associated with sensitivity to beta(1)-adrenergic blockade in humans.

Pharmacogenomics - 1 Oct 2009

Kurnik Daniel, Cunningham Andrew J, Sofowora Gbenga G, Kohli Utkarsh, Li Chun, Friedman Eitan A, Muszkat Mordechai, Menon Usha B, Wood Alastair Jj, Stein C Michael

Abstract excerpt

AIMS: A common, functionally significant polymorphism in GRK5 (Gln41Leu) encodes a gain-of-function enzyme that enhances desensitization of the beta(1)-adrenergic receptor. GRK5 Leu41 has been postulated to confer endogenous 'genetic beta-blockade' and contribute to an attenuated response to beta-blockers in black subjects. The effects of this GRK5 variant on sensitivity to a beta-blocker have not been studied in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19842931
DOI: 10.2217/pgs.09.92
PMCID: PMC2820245

Genes

GRK5
ADRB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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