Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy.

doi:10.1002/cpt.3351

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Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy.

Clinical pharmacology and therapeutics - 1 Oct 2024

Duarte Julio D, Thomas Cameron D, Lee Craig R, Huddart Rachel, Agundez Jose A G, Baye Jordan F, Gaedigk Andrea, Klein Teri E, Lanfear David E, Monte Andrew A, Nagy Mohamed, Schwab Matthias, Stein C Michael, Uppugunduri Chakradhara Rao S, van Schaik Ron H N, Donnelly Roseann S, Caudle Kelly E, Luzum Jasmine A

Abstract excerpt

Beta-blockers are widely used medications for a variety of indications, including heart failure, myocardial infarction, cardiac arrhythmias, and hypertension. Genetic variability in pharmacokinetic (e.g., CYP2D6) and pharmacodynamic (e.g., ADRB1, ADRB2, ADRA2C, GRK4, GRK5) genes have been studied in relation to beta-blocker exposure and response. We searched and summarized the strength of the evidence linking...

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Identifiers

PMID: 38951961
DOI: 10.1002/cpt.3351
PMCID: PMC11502236

Genes

ADRA2C
ADRB1
ADRB2
GRK4
GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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