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Haplo‐insufficiency: a driving force in cancer

6 Oct 2010

Abstract excerpt

It was originally proposed that tumour suppressor genes (TSGs) act in a recessive manner. Instead, numerous TSGs, including p53 and PTEN, exhibit haplo-insufficiency as a consequence of the dose-dependency of TSG function. Due to the challenges of identifying haplo-insufficient TSGs by human genetics analysis alone, mouse models play a pivotal role in firmly establishing the haplo-insufficiency of a gene, as in...

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PMID: 21125671
DOI: 10.1002/path.2800

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