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Article

Allelic phasing of a mouse chromosome 11 deficiency influences p53 tumorigenicity.

Oncogene - 22 May 2003

Biggs Patrick J, Vogel Hannes, Sage Marijke, Martin Lucy A, Donehower Larry A, Bradley Allan

Abstract excerpt

Most tumour suppressor genes (TSGs) have been found through linkage studies in cancer predisposed families where the mutations have a high penetrance, for example, the breast cancer genes BRCA1 and BRCA2. Loss of heterozygosity (LOH) analyses of sporadic breast tumours indicate that there are many other putative TSGs yet to be identified. One such locus is proximal to BRCA1 on human chromosome 17q21. In an...

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Share to Chromosome Deletion
Share to Chromosomes, Mammalian
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genes, Tumor Suppressor

Share to Loss of Heterozygosity

Share to Mice, Inbred C57BL

Share to Neoplasms, Experimental

Source

Identifiers

PMID: 12761499
DOI: 10.1038/sj.onc.1206384

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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