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Article

Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance.

Cellular and molecular life sciences : CMLS - 1 Mar 2012

Cabelof Diane C

Abstract excerpt

Mouse models of DNA repair deficiency are useful tools for determining susceptibility to disease. Cancer predisposition and premature aging are commonly impacted by deficiencies in DNA repair, presumably as a function of reduced genomic fitness. In this review, a comprehensive analysis of all DNA repair mutant mouse models has been completed in order to assess the importance of haploinsufficiency for these genes....

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Identifiers

PMID: 21952828
DOI: 10.1007/s00018-011-0839-7
PMCID: PMC11114761

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