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Article

Identification of DOK genes as lung tumor suppressors.

Nature genetics - 1 Mar 2010

Berger Alice H, Niki Masaru, Morotti Alessandro, Taylor Barry S, Socci Nicholas D, Viale Agnes, Brennan Cameron, Szoke Janos, Motoi Noriko, Rothman Paul B, Teruya-Feldstein Julie, Gerald William L, Ladanyi Marc, Pandolfi Pier Paolo

Abstract excerpt

Genome-wide analyses of human lung adenocarcinoma have identified regions of consistent copy-number gain or loss, but in many cases the oncogenes and tumor suppressors presumed to reside in these loci remain to be determined. Here we identify the downstream of tyrosine kinase (Dok) family members...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

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Source

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Identifiers

PMID: 20139980
DOI: 10.1038/ng.527
PMCID: PMC2956443

Genes

DOK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20139980-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of DOK genes as lung tumor suppressors.PMID 20139980Read ↗

DOK2 inhibits EGFR-mutated lung adenocarcinoma.Semantic proximity Read ↗

Comprehensive analysis of Downstream of Kinase (DOK) Genes in Pan-cancerSemantic proximity Read ↗

Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer.Semantic proximity Read ↗

EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk.Semantic proximity Read ↗

A catalog of genes homozygously deleted in human lung cancer and the candidacy of PTPRD as a tumor suppressor gene.Semantic proximity Read ↗

Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer.Semantic proximity Read ↗

Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites.Semantic proximity Read ↗

Identification of Dok-4b, a Dok-4 splice variant with enhanced inhibitory properties.Semantic proximity Read ↗

DOK7 Inhibits Cell Proliferation, Migration, and Invasion of Breast Cancer via the PI3K/PTEN/AKT PathwaySemantic proximity Read ↗

SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers.Semantic proximity Read ↗

Loss of DOK2 induces carboplatin resistance in ovarian cancer via suppression of apoptosisSemantic proximity Read ↗

Dok1 expression and mutation in Burkitt's lymphoma cell lines.Semantic proximity Read ↗

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