Article
Impact of uPA system gene polymorphisms on the susceptibility of environmental factors to carcinogenesis and the development of clinicopathology of oral cancer.
Annals of surgical oncology - 1 Mar 2011
Weng Chia-Jui, Lin Chiao-Wen, Chung Tsung-Te, Tsai Chiung-Man, Chen Mu-Kuan, Yang Shun-Fa
Abstract excerpt
BACKGROUND: The levels of urokinase plasminogen activator (uPA) system in tumor tissues are implicated as prognostic biomarkers in a wide range of malignancies. However, their possible impact on the risk and prognosis of oral cancer and the susceptibility of environmental carcinogens to oral cancer remains poorly investigated. METHODS: The genetic polymorphisms of uPA, uPA receptor (uPAR), and plasminogen...
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