Article
Evaluation of the association of urokinase plasminogen activator system gene polymorphisms with susceptibility and pathological development of hepatocellular carcinoma.
Annals of surgical oncology - 1 Dec 2010
Weng Chia-Jui, Tsai Chiung-Man, Chen Yi-Chen, Hsieh Yi-Hsien, Lin Chiao-Wen, Liu Yu-Fan, Su Shih-Chi, Chen Mu-Kuan, Yang Shun-Fa
Abstract excerpt
BACKGROUND: The urokinase plasminogen activator (uPA) system is a serine proteinase system involved in extracellular matrix (ECM) degradation. The levels of uPA system components in tumor tissues are implicated as prognostic biomarkers in a wide range of malignancies. Although the contributions of uPA system components to the formation of many types of cancer are well known, their possible association with the...
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