Phenotyping of human tumor-infiltrating lymphocytes before and after exposure to different in vitro stimulation conditions.

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Article

Phenotyping of human tumor-infiltrating lymphocytes before and after exposure to different in vitro stimulation conditions.

Anticancer research - 1 Jan 2000

Wimmenauer S, Wintzer H O, von Kleist S

Abstract excerpt

Tumor-infiltrating lymphocytes (TiL) and autologous peripheral blood lymphocytes (PBL), mainly from breast and kidney tumor patients were cultivated with high- and low-dose rIL-2 under addition of autologous tumor cells or nonmalignant epithelial cells. Tumor cells added to TIL-cultures induced an additional proliferative response. Before cultivation, CD8+ and CD25+ lymphocytes were more frequent in TIL when...

Topics

Aged
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
CD2 Antigens
CD4 Antigens
CD56 Antigen
CD8 Antigens
Cells, Cultured
Female
HLA-DR Antigens
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-2

Lymphocyte Activation

Lymphocytes, Tumor-Infiltrating

Male

Middle Aged

Phenotype

Receptors, Immunologic

Source

Open in PubMed

Identifiers

PMID: 1716082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1716082-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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