Article
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
PloS one - 18 Nov 2010
Bell Christopher G, Finer Sarah, Lindgren Cecilia M, Wilson Gareth A, Rakyan Vardhman K, Teschendorff Andrew E, Akan Pelin, Stupka Elia, Down Thomas A, Prokopenko Inga, Morison Ian M, Mill Jonathan, Pidsley Ruth, Deloukas Panos, Frayling Timothy M, Hattersley Andrew T, McCarthy Mark I, Beck Stephan, Hitman Graham A
Abstract excerpt
Recent multi-dimensional approaches to the study of complex disease have revealed powerful insights into how genetic and epigenetic factors may underlie their aetiopathogenesis. We examined genotype-epigenotype interactions in the context of Type 2 Diabetes (T2D), focussing on known regions of genomic susceptibility. We assayed DNA methylation in 60 females, stratified according to disease susceptibility...
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