Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study.

doi:10.1186/s12933-024-02558-8

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Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study.

Cardiovascular diabetology - 18 Jan 2025

Lai Liye, Juntilla Dave Laurence, Del C Gomez-Alonso Monica, Grallert Harald, Thorand Barbara, Farzeen Aiman, Rathmann Wolfgang, Winkelmann Juliane, Prokisch Holger, Gieger Christian, Herder Christian, Peters Annette, Waldenberger Melanie

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) has been linked to changes in DNA methylation levels, which can, in turn, alter transcriptional activity. However, most studies for epigenome-wide associations between T2D and DNA methylation comes from cross-sectional design. Few large-scale investigations have explored these associations longitudinally over multiple time-points. METHODS: In this longitudinal study, we examined...

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