Article
Novel epigenetic determinants of type 2 diabetes in Mexican-American families.
Human molecular genetics - 15 Sept 2015
Kulkarni Hemant, Kos Mark Z, Neary Jennifer, Dyer Thomas D, Kent Jack W, Göring Harald H H, Cole Shelley A, Comuzzie Anthony G, Almasy Laura, Mahaney Michael C, Curran Joanne E, Blangero John, Carless Melanie A
Abstract excerpt
Although DNA methylation is now recognized as an important mediator of complex diseases, the extent to which the genetic basis of such diseases is accounted for by DNA methylation is unknown. In the setting of large, extended families representing a minority, high-risk population of the USA, we aimed to characterize the role of epigenome-wide DNA methylation in type 2 diabetes (T2D). Using Illumina...
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