Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.

Molecular and cellular biology - 1 Aug 2007

Bolland Daniel J, Wood Andrew L, Afshar Roshi, Featherstone Karen, Oltz Eugene M, Corcoran Anne E

Abstract excerpt

V(D)J recombination is believed to be regulated by alterations in chromatin accessibility to the recombinase machinery, but the mechanisms responsible remain unclear. We previously proposed that antisense intergenic transcription, activated throughout the mouse Igh VH region in pro-B cells, remod...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Antisense
Share to DNA, Intergenic
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin Heavy Chain

Share to Germ Cells

Share to Homeodomain Proteins

Share to Introns

Share to Transcription Initiation Site

Source

Open in PubMed Open full text

Identifiers

PMID: 17526723
DOI: 10.1128/MCB.02407-06
PMCID: PMC1952079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17526723-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.PMID 17526723Read ↗

The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.Semantic proximity Read ↗

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.Semantic proximity Read ↗

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.Semantic proximity Read ↗

B cell development arrest upon insertion of a neo gene between JH and Emu: promoter competition results in transcriptional silencing of germline JH and complete VDJ rearrangements.Semantic proximity Read ↗

The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation.Semantic proximity Read ↗

Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.Semantic proximity Read ↗

Elucidation of IgH intronic enhancer functions via germ-line deletionSemantic proximity Read ↗

C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon.Semantic proximity Read ↗

The IgH <i>Eμ</i> -MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutationSemantic proximity Read ↗

A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.Semantic proximity Read ↗

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletionSemantic proximity Read ↗

Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.