Article
Antitumor activities of interferon alpha, beta, and gamma and their combinations on human melanoma cells in vitro: changes of proliferation, melanin synthesis, and immunophenotype.
The Journal of investigative dermatology - 1 Dec 1990
Garbe C, Krasagakis K, Zouboulis C C, Schröder K, Krüger S, Stadler R, Orfanos C E
Abstract excerpt
The antitumor activities of human interferon (IFN) alpha, beta, and gamma alone or in combination were studied on four human melanoma cell lines (StML-11, StML-12, StML-14, and SKMel-28) in various concentrations (1-50,000 IU/ml IFN alpha, 0.1-1000 IU/ml IFN beta, 1-10,000 IU/ml IFN gamma) in vitro. In all experiments IFN beta exhibited the most potent antiproliferative effect of all IFN tested. After 3 d of...
Topics
- Cell Differentiation
- Cell Division
- Drug Combinations
- Humans
- Immunologic Techniques
- Interferon Type I
- Interferon-gamma
- Melanins
- Melanoma
- Phenotype