Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant melanoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2003

Propper David J, Chao David, Braybrooke Jeremy P, Bahl Pru, Thavasu Parames, Balkwill Frances, Turley Helen, Dobbs Nicola, Gatter Kevin, Talbot Denis C, Harris Adrian L, Ganesan Trivadi S

Abstract excerpt

Specific antitumor immune responses require expression of MHC class I or II molecules on tumor cells, and MHC antigen down-regulation is a presumed tumor growth promoting mechanism. Because IFN-gamma up-regulates tumor MHC antigen expression in vitro, in this Phase II trial of an immunologically active dose and schedule we evaluated whether this was the case in vivo. Twenty-three patients with metastatic melanoma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to beta 2-Microglobulin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, MHC Class I

Share to Genes, MHC Class II

Share to Immunotherapy

Share to Intercellular Adhesion Molecule-1

Share to Interferon-gamma

Share to Major Histocompatibility Complex

Source

Identifiers

PMID: 12538455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant melanoma.PMID 12538455Read ↗

Effects of systemic interferon-alpha (IFN-alpha) on the antigenic phenotype of melanoma metastases. EORTC melanoma group cooperative study No. 18852.Semantic proximity Read ↗

Locus-Specific Analysis of Human Leukocyte Antigen Class I Expression in Melanoma Cell LinesSemantic proximity Read ↗

Immunomodulatory effects of high-dose and low-dose interferon alpha2b in patients with high-risk resected melanoma: the E2690 laboratory corollary of intergroup adjuvant trial E1690.Semantic proximity Read ↗

Immune escape phenotype of HPV16-associated tumours: MHC class I expression changes during progression and therapy.Semantic proximity Read ↗

Unbalanced expression of HLA-A and -B antigens: a specific feature of cutaneous melanoma and other non-hemopoietic malignancies reverted by IFN-gamma.Semantic proximity Read ↗

Effects of cyclophosphamide and IL-2 on regulatory CD4+ T cell frequency and function in melanoma patients vaccinated with HLA-class I peptides: impact on the antigen-specific T cell response.Semantic proximity Read ↗

Decreased intraindividual HLA class I expression is due to reduced transcription in advanced melanoma and does not correlate with HLA-G expression.Semantic proximity Read ↗

Characterization of interferon-γ-treated melanoma tumor cells for use in dendritic cell-based immunotherapy.Semantic proximity Read ↗

Selective upregulation of MHC class I expression in metastatic colonies derived from tumor clones of a murine fibrosarcoma.Semantic proximity Read ↗

High frequency of allele-specific down-regulation of HLA class I expression in uveal melanoma cell lines.Semantic proximity Read ↗

Regulation of the antigenic phenotype of human melanoma cells by recombinant interferons.Semantic proximity Read ↗

Phase I trial of intravenous peptide-pulsed dendritic cells in patients with metastatic melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.