Article
Biological and clinical effects of the oral immunomodulator 3,6-bis(2-piperidinoethoxy)acridine trihydrochloride in patients with malignancy.
Journal of biological response modifiers - 1 Feb 1990
Litton G J, Hong R, Grossberg S E, Vechlekar D, Goodavish C N, Borden E C
Abstract excerpt
CL 246,738 is a synthetic heterocyclic of the acridine class that has immunomodulating, interferon (IFN)-inducing, and antitumor activity by the oral route in mice. We have completed a phase I ascending dose trial to determine the maximum tolerated oral dose and biologic modifying effects. Twenty...
Topics
- 2',5'-Oligoadenylate Synthetase
- Acridines
- Adjuvants, Immunologic
- Administration, Oral
- Antineoplastic Agents
- Cell Division
- Cytotoxicity Tests, Immunologic
- Drug Evaluation
- Female
- Humans
- In Vitro Techniques
- Interferons
- Male
- Phenotype
- T-Lymphocytes
- beta 2-Microglobulin