Article

Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data

2024-08-16

Abstract excerpt

Single-cell RNA-seq (scRNA-seq) is emerging as a powerful tool for understanding gene function across diverse cells. Recently, this has included the use of allele-specific expression (ASE) analysis to better understand how variation in the human genome affects RNA expression at the single-cell level. We reasoned that because intronic reads are more prevalent in single-nucleus RNA-Seq (snRNA-Seq), and introns are u...

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Literature Corpus work: a4ecac5d-6863-5d54-b1a9-ed685b8a8c06
DOI: 10.1101/2024.08.13.607784

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