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Article

Irrelevance of CHEK2 variants to diagnosis of breast/ovarian cancer predisposition in Polish cohort.

Journal of applied genetics - 1 May 2011

Myszka Aleksander, Karpinski Pawel, Slezak Ryszard, Czemarmazowicz Halina, Stembalska Agnieszka, Gil Justyna, Laczmanska Izabela, Bednarczyk Damian, Szmida Elzbieta, Sasiadek Maria Malgorzata

Abstract excerpt

CHEK2 gen encodes cell cycle checkpoint kinase 2 that participates in the DNA repair pathway, cell cycle regulation and apoptosis. Mutations in CHEK2 gene may result in kinase inactivation or reduce both catalytic activity and capability of binding other proteins. Some studies indicate that alterations in CHEK2 gene confers increase the risk of breast cancer and some other malignancies, while the results of other...

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Identifiers

PMID: 21120647
DOI: 10.1007/s13353-010-0013-1

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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