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CHEK2-related breast cancer: real-world challenges.

Familial cancer - 18 Feb 2025

Weis Luiza N, Bychkovsky Brittany L, Hernandez Adela Rodríguez, Barroso-Sousa Romualdo, Sandoval Renata L

Abstract excerpt

PURPOSE: Management of cancer risks associated with the CHEK2 gene, a moderate penetrance breast cancer gene, is challenging in real-world practice. Family history, traditional breast cancer risk factors, and specific genetic CHEK2 variants are risk modifiers in this setting and add complexity for surveillance and risk-reduction decisions. Here, we present a case series of Brazilian CHEK2 carriers affected by...

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Identifiers

PMID: 39966186
DOI: 10.1007/s10689-025-00448-w

Genes

CHEK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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