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Article

[CHEK2 and breast cancer risk].

Bulletin du cancer - 1 Nov 2002

Coupier Isabelle, Stoppa-Lyonnet Dominique

Abstract excerpt

The BRCA1 et BRCA2 genes are involved in 2/3 of genetic predisposition with major risk of breast cancer. One or more genes remain to be identified. The CHEK2 gene is a good candidate. The CHEK2 gene mutation 1100delC is associated with a moderate increase of breast cancer risk (RR = 2). CHEK2 is probably one of the genetic factors associated with moderate risk, but however when associated with other variants, it...

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Source

Identifiers

PMID: 12495879

Genes

CHEK2
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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[CHEK2 and breast cancer risk].PMID 12495879Read ↗

[CHEK2-mutation in Dutch breast cancer families: expanding genetic testing for breast cancer].Semantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial studySemantic proximity Read ↗

Is CHEK2 a moderate-risk breast cancer gene or the younger sister of Li-Fraumeni?Semantic proximity Read ↗

Irrelevance of CHEK2 variants to diagnosis of breast/ovarian cancer predisposition in Polish cohort.Semantic proximity Read ↗

Chek2 DNA damage response pathway and inherited breast cancer risk.Semantic proximity Read ↗

[Breast cancer susceptibility genes].Semantic proximity Read ↗

Identification of a novel BRCA2 and CHEK2 A-C-G-C haplotype in Turkish patients affected with breast cancer.Semantic proximity Read ↗

A CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast CancerSemantic proximity Read ↗

Current perspectives on CHEK2 mutations in breast cancerSemantic proximity Read ↗

[The clinical importance of a genetic analysis of moderate-risk cancer susceptibility genes in breast and other cancer patients from the Czech Republic].Semantic proximity Read ↗

The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech RepublicSemantic proximity Read ↗

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