Article
LRP5 gene polymorphism and cortical bone.
Aging clinical and experimental research - 1 Aug 2010
Lauretani Fulvio, Cepollaro Chiara, Bandinelli Stefania, Cherubini Antonio, Gozzini Alessia, Masi Laura, Falchetti Alberto, Del Monte Francesca, Carbonell-Sala Silvia, Marini Francesca, Tanini Annalisa, Corsi Anna Maria, Ceda Gian Paolo, Brandi Maria Luisa, Ferrucci Luigi
Abstract excerpt
BACKGROUND AND AIMS: There is evidence that distinct genetic polymorphisms of LRP5 are associated with low Bone Mineral Density (BMD) and the risk of fracture. However, relationships between LRP5 polymorphisms and micro- and macro architectural bone characteristics assessed by pQCT have not been studied. The aim of the present study was to investigate the association of Ala1330Val and Val667Met polymorphisms in...
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