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Article

The impact of LRP5 polymorphism (rs556442) on calcium homeostasis, bone mineral density, and body composition in Iranian children.

Journal of bone and mineral metabolism - 1 Nov 2015

Ashouri Elham, Meimandi Elham Mahmoodi, Saki Forough, Dabbaghmanesh Mohammad Hossein, Omrani Gholamhossein Ranjbar, Bakhshayeshkaram Marzieh

Abstract excerpt

Failure to achieve optimal bone mass in childhood is the primary cause of decreased adult bone mineral density (BMD) and increased bone fragility in later life. Activating and inactivating LRP5 gene mutations has been associated with extreme bone-related phenotypes. Our aim was to investigate the role of LRP5 polymorphism on BMD, mineral biochemical parameters, and body composition in Iranian children. This...

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Identifiers

PMID: 25515155
DOI: 10.1007/s00774-014-0624-4

Genes

LRP5

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