Article
LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women.
Bone - 1 Apr 2005
Bollerslev J, Wilson S G, Dick I M, Islam F M A, Ueland T, Palmer L, Devine A, Prince R L
Abstract excerpt
Postmenopausal osteoporosis and bone mass are influenced by multiple factors including genetic variation. The importance of LDL receptor-related protein 5 (LRP5) for the regulation of bone mass has recently been established, where loss of function mutations is followed by severe osteoporosis and gain of function is related to increased bone mass. The aim of this study was to evaluate the role of polymorphisms in...
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