Article
Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression.
Molecular and cellular biology - 1 Jun 1990
Libermann T A, Lenardo M, Baltimore D
Abstract excerpt
To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene, we have investigated the effect of mutating the binding site for a putative additional lymphoid-s...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Cell Line
- Cells, Cultured
- Chloramphenicol O-Acetyltransferase
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin mu-Chains
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Oligonucleotide Probes
- Restriction Mapping