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Article

Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression.

Molecular and cellular biology - 1 Jun 1990

Libermann T A, Lenardo M, Baltimore D

Abstract excerpt

To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene, we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor, designated NF-microB, in the murine IgH enhancer. We demonstrate that the...

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Identifiers

PMID: 2111447
DOI: 10.1128/mcb.10.6.3155-3162.1990
PMCID: PMC360680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression.PMID 2111447Read ↗

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Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation.Semantic proximity Read ↗

A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor.Semantic proximity Read ↗

NF-kappa B activity is required for the deregulation of c-myc expression by the immunoglobulin heavy chain enhancer.Semantic proximity Read ↗

Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins.Semantic proximity Read ↗

Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.Semantic proximity Read ↗

Exploring functional redundancy in the immunoglobulin mu heavy-chain gene enhancer.Semantic proximity Read ↗

Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers.Semantic proximity Read ↗

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An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity.Semantic proximity Read ↗

Selective utilization of basic helix-loop-helix-leucine zipper proteins at the immunoglobulin heavy-chain enhancer.Semantic proximity Read ↗

Roles of the Ig κ Light Chain Intronic and 3′ Enhancers in Igk Somatic HypermutationSemantic proximity Read ↗

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