A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor.

doi:10.1111/j.1432-1033.1990.tb15332.x

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Article

A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor.

European journal of biochemistry - 14 Feb 1990

Elmaleh N, Matthias P, Schaffner W

Abstract excerpt

The transcriptional enhancer located in the first intron of the immunoglobulin heavy chain constant region is a major determinant of B-cell-specific expression of immunoglobulin genes. Like other enhancers, the Ig heavy chain enhancer contains several short sequence motifs that bind specific transcription factors. Each binding site contributes to the overall activity of the enhancer, however no single element...

Topics

B-Lymphocytes
Base Sequence
Binding Sites
Cloning, Molecular
DNA-Binding Proteins
Enhancer Elements, Genetic
Genes, Regulator
HeLa Cells
Humans
Immunoglobulin Heavy Chains
Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylation

Molecular Sequence Data

Mutation

Promoter Regions, Genetic

Transcription Factors

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 2105887
DOI: 10.1111/j.1432-1033.1990.tb15332.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2105887-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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