Article
Regulation of lymphoid-specific immunoglobulin mu heavy chain gene enhancer by ETS-domain proteins.
Science (New York, N.Y.) - 2 Jul 1993
Nelsen B, Tian G, Erman B, Gregoire J, Maki R, Graves B, Sen R
Abstract excerpt
The enhancer for the immunoglobulin mu heavy chain gene (IgH) activates a heterologous gene at the pre-B cell stage of B lymphocyte differentiation. A lymphoid-specific element, microB, is necessary for enhancer function in pre-B cells. A microB binding protein is encoded by the PU.1/Spi-1 proto-...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Cell Differentiation
- Cell Line
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Female
- Genes, Immunoglobulin
- Humans
- Immunoglobulin mu-Chains
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Mas
- Proto-Oncogene Protein c-ets-1
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ets