Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation.

doi:10.1093/intimm/7.8.1163

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Article

Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation.

International immunology - 1 Aug 1995

Yuan D, Dang T, Hawley J, Jenuwein T, Grosschedl R

Abstract excerpt

We have evaluated the importance of the OCTA site in both the promoter and enhancer regions for the induction of enhancement of IgH chain gene transcription after B cell activation. These studies show that although occupancy of the OCTA site in the promoter is critical for basal transcription of the mu gene, it is not necessary for the increase in transcription induced by in vivo activation. On the other hand,...

Topics

Animals
B-Lymphocytes
Base Sequence
Bone Marrow
Bone Marrow Cells
Enhancer Elements, Genetic
Gene Expression Regulation
Genes, Immunoglobulin
Immunoglobulin Heavy Chains
Immunoglobulin M
Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Mice

Mice, Inbred C57BL

Mice, Transgenic

Molecular Sequence Data

Mutation

Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 7495723
DOI: 10.1093/intimm/7.8.1163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7495723-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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