Article
Differentiation-specific, octamer-dependent costimulation of kappa transcription.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1998
Liberg D, Sigvardsson M, Bemark M, Leanderson T
Abstract excerpt
By mutational analysis of the octamer-TATA box intervening region in the mouse SP6 kappa promoter, we have mapped two octamer-dependent, costimulatory regions, A and B. The A region was active in late B cells only, while the B region was active throughout B cell differentiation. The B region was...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Cell Differentiation
- Cell Line
- DNA
- Genes, Immunoglobulin
- Humans
- Mice
- Models, Biological
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- TATA Box
- Transcription Factors
- Transcription, Genetic