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Article

Differentiation-specific, octamer-dependent costimulation of kappa transcription.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1998

Liberg D, Sigvardsson M, Bemark M, Leanderson T

Abstract excerpt

By mutational analysis of the octamer-TATA box intervening region in the mouse SP6 kappa promoter, we have mapped two octamer-dependent, costimulatory regions, A and B. The A region was active in late B cells only, while the B region was active throughout B cell differentiation. The B region was TATA proximal and contained a heptamer and an E box of the E2A type that is common in Vkappa promoters. Mutation of the...

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PMID: 9558096

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