Article
The immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription.
Molecular and cellular biology - 1 Jun 1990
Su L K, Kadesch T
Abstract excerpt
We demonstrate that the immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription. The enhancer itself, when placed 5' to the bacterial cat or neo genes, is able to direct transcription by using heterogeneous start sites that are generally the same as those found with bona fide I mu transcripts. In general, promoter activity is dependent on the same sequence motifs important for...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Cell Line
- Chloramphenicol O-Acetyltransferase
- Enhancer Elements, Genetic
- Immunoglobulin Heavy Chains
- Mice
- Molecular Sequence Data
- Mutation
- Plasmids