Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription.

Molecular and cellular biology - 1 Jun 1990

Su L K, Kadesch T

Abstract excerpt

We demonstrate that the immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription. The enhancer itself, when placed 5' to the bacterial cat or neo genes, is able to direct transcription by using heterogeneous start sites that are generally the same as those found with bona fide I mu transcripts. In general, promoter activity is dependent on the same sequence motifs important for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Share to Restriction Mapping

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2111440
DOI: 10.1128/mcb.10.6.2619-2624.1990
PMCID: PMC360620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The immunoglobulin heavy-chain enhancer functions as the promoter for I mu sterile transcription.PMID 2111440Read ↗

C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon.Semantic proximity Read ↗

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity.Semantic proximity Read ↗

B cell development arrest upon insertion of a neo gene between JH and Emu: promoter competition results in transcriptional silencing of germline JH and complete VDJ rearrangements.Semantic proximity Read ↗

Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions.Semantic proximity Read ↗

Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.Semantic proximity Read ↗

Transcription, beta-like DNA polymerases and hypermutation.Semantic proximity Read ↗

The mouse ribosomal DNA promoter has more stringent requirements in vivo than in vitro.Semantic proximity Read ↗

Functional analysis of defined mutations in the immunoglobulin heavy-chain enhancer in transgenic mice.Semantic proximity Read ↗

Characterization of SV40 enhancer motifs involved in positive and negative regulation of the constitutive late promoter activity; effect of T-antigen.Semantic proximity Read ↗

The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.Semantic proximity Read ↗

Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.