Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2008

Kuzin Igor I, Bagaeva Ludmila, Young Faith M, Bottaro Andrea

Abstract excerpt

The intronic Emicro enhancer has been implicated in IgH locus transcription, VDJ recombination, class switch recombination, and somatic hypermutation. How Emicro controls these diverse mechanisms is still largely unclear, but transcriptional enhancer activity is thought to play a central role. In this study we compare the phenotype of mice lacking the Emicro element (DeltaEmicro) with that of mice in which Emu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Bone Marrow
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Share to Genes, Immunoglobulin Heavy Chain

Share to Immunoglobulin Heavy Chains

Share to Mice, Mutant Strains

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 18490744
DOI: 10.4049/jimmunol.180.11.7443
PMCID: PMC2408828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation.PMID 18490744Read ↗

B cell development arrest upon insertion of a neo gene between JH and Emu: promoter competition results in transcriptional silencing of germline JH and complete VDJ rearrangements.Semantic proximity Read ↗

Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.Semantic proximity Read ↗

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.Semantic proximity Read ↗

Elucidation of IgH intronic enhancer functions via germ-line deletionSemantic proximity Read ↗

A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.Semantic proximity Read ↗

Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.Semantic proximity Read ↗

The IgH <i>Eμ</i> -MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutationSemantic proximity Read ↗

Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.Semantic proximity Read ↗

Mechanisms of mu enhancer regulation in B lymphocytes.Semantic proximity Read ↗

Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.Semantic proximity Read ↗

Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.Semantic proximity Read ↗

The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.