Article
Functional analysis of defined mutations in the immunoglobulin heavy-chain enhancer in transgenic mice.
Nucleic acids research - 11 Apr 1992
Annweiler A, Müller U, Wirth T
Abstract excerpt
We have analyzed the effect of defined mutations in the mouse immunoglobulin heavy-chain enhancer after introduction into the germline of transgenic mice. We have tested a mutation of the enhancer octamer motif, a double mutation of the octamer motif and the microB-site, and a triple mutation in...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genes, Immunoglobulin
- Globins
- Glyceraldehyde-3-Phosphate Dehydrogenases
- Immunoglobulin mu-Chains
- Introns
- Lymphocyte Activation