Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions.

Nucleic acids research - 25 Oct 1993

Fulton R, Van Ness B

Abstract excerpt

We have investigated the interaction of the kappa immunoglobulin light chain intron and 3' enhancers with two different kappa promoters at distinct stages of B-cell development. We find that transiently transfected reporter gene constructs driven by either the kappa V-region promoter, or the kappa germline promoter, are controlled by the known enhancers of the locus in a developmentally regulated fashion. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Line
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Promoter Regions, Genetic

Share to Transcription, Genetic

Share to Transfection

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 8177743
DOI: 10.1093/nar/21.21.4941
PMCID: PMC311410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions.PMID 8177743Read ↗

Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers.Semantic proximity Read ↗

Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.Semantic proximity Read ↗

The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.Semantic proximity Read ↗

Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression.Semantic proximity Read ↗

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.Semantic proximity Read ↗

Chromatin Structural Analyses of the Mouse Igκ Gene Locus Reveal New Hypersensitive Sites Specifying a Transcriptional Silencer and EnhancerSemantic proximity Read ↗

A targeted kappa immunoglobulin gene containing a deletion of the nuclear matrix association region exhibits spontaneous hyper-recombination in pre-B cells.Semantic proximity Read ↗

Dynamic changes in accessibility, nuclear positioning, recombination, and transcription at the Ig kappa locus.Semantic proximity Read ↗

Mechanisms of mu enhancer regulation in B lymphocytes.Semantic proximity Read ↗

Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.Semantic proximity Read ↗

The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes.Semantic proximity Read ↗

Activation of c-myc promoter P1 by immunoglobulin kappa gene enhancers in Burkitt lymphoma: functional characterization of the intron enhancer motifs kappaB, E box 1 and E box 2, and of the 3' enhancer motif PU.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.