Article
Kappa immunoglobulin promoters and enhancers display developmentally controlled interactions.
Nucleic acids research - 25 Oct 1993
Fulton R, Van Ness B
Abstract excerpt
We have investigated the interaction of the kappa immunoglobulin light chain intron and 3' enhancers with two different kappa promoters at distinct stages of B-cell development. We find that transiently transfected reporter gene constructs driven by either the kappa V-region promoter, or the kappa germline promoter, are controlled by the known enhancers of the locus in a developmentally regulated fashion. We...
Topics
- Animals
- B-Lymphocytes
- Cell Differentiation
- Cell Line
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Immunoglobulin kappa-Chains
- Introns
- Lipopolysaccharides
- Mice
- Mutation