Article
Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.
Biochemistry - 21 Aug 2007
Drosatos Konstantinos, Kypreos Kyriakos E, Zannis Vassilis I
Abstract excerpt
Overexpression of apolipoprotein E (apoE) induces hypertriglyceridemia in apoE-deficient mice, which is abrogated by deletion of the carboxy-terminal segment of residues 260-299. We have used adenovirus-mediated gene transfer in apoE-/- and apoA-I-/- mice to test the effect of three sets of apoE mutations within the region of residues 261-265 on the induction of hypertriglyceridemia, the esterification of...
Topics
- Adenoviridae
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Apolipoprotein E2
- Apolipoprotein E4
- Cholesterol
- Humans
- Hypertriglyceridemia
- Leucine
- Lipoproteins, HDL
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data