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Article

Effects of polymorphism on the lipid interaction of human apolipoprotein E.

The Journal of biological chemistry - 17 Oct 2003

Saito Hiroyuki, Dhanasekaran Padmaja, Baldwin Faye, Weisgraber Karl H, Phillips Michael C, Lund-Katz Sissel

Abstract excerpt

ApoE exists as three common isoforms, apoE2, apoE3, and apoE4; apoE2 and apoE3 preferentially bind to high density lipoproteins, whereas apoE4 prefers very low density lipoproteins (VLDL). To understand the molecular basis for the different lipoprotein distributions of these isoforms in human plasma, we examined the lipid-binding properties of the apoE isoforms and some mutants using lipid emulsions. With both...

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PMID: 12917433
DOI: 10.1074/jbc.M304814200

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