Article
The floor plate is sufficient for development of the sclerotome and spine without the notochord.
Mechanisms of development - 1 Jan 2000
Ando Takashi, Semba Kei, Suda Hiroko, Sei Akira, Mizuta Hiroshi, Araki Masatake, Abe Kuniya, Imai Kenji, Nakagata Naomi, Araki Kimi, Yamamura Ken-ichi
Abstract excerpt
Danforth'sshort-tail (Sd) mouse is a semi-dominant mutation affecting the development of the vertebral column. Although the notochord degenerates completely by embryonic day 9.5, the vertebral column exists up to the lumber region, suggesting that the floor plate can substitute for notochord function. We previously established the mutant mouse line, Skt(Gt), through gene trap mutagenesis and identified the novel...
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