Article
Production of Wnt4b by floor plate cells is essential for the segmental patterning of the vertebral column in medaka.
Development (Cambridge, England) - 1 Jun 2010
Inohaya Keiji, Takano Yoshiro, Kudo Akira
Abstract excerpt
The floor plate is a key organizer that controls the specification of neurons in the central nervous system. Here, we show a new role of the floor plate: segmental pattern formation of the vertebral column. Analysis of a spontaneous medaka mutant, fused centrum (fsc), which exhibits fused centra and the absence of the intervertebral ligaments, revealed that fsc encodes wnt4b, which was expressed exclusively in...
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