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Article

A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae.

Development (Cambridge, England) - 1 Nov 1993

Koseki H, Wallin J, Wilting J, Mizutani Y, Kispert A, Ebensperger C, Herrmann B G, Christ B, Balling R

Abstract excerpt

The notochord plays an important role in the differentiation of the paraxial mesoderm and the neural tube. We have analyzed the role of the notochord in somite differentiation and subsequent formation of the vertebral column using a mouse mutant, Danforth's short-tail (Sd). In this mutant, the skeletal phenotype is most probably a result of degeneration and subsequent loss of the notochord. The Sd gene is known...

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Identifiers

PMID: 8187635
DOI: 10.1242/dev.119.3.649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae.PMID 8187635Read ↗

The role of Pax-1 in axial skeleton development.Semantic proximity Read ↗

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Genetic interactions suggest that Danforth's short tail (Sd) is a gain-of-function mutation.Semantic proximity Read ↗

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Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development.Semantic proximity Read ↗

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