Article
A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae.
Development (Cambridge, England) - 1 Nov 1993
Koseki H, Wallin J, Wilting J, Mizutani Y, Kispert A, Ebensperger C, Herrmann B G, Christ B, Balling R
Abstract excerpt
The notochord plays an important role in the differentiation of the paraxial mesoderm and the neural tube. We have analyzed the role of the notochord in somite differentiation and subsequent formation of the vertebral column using a mouse mutant, Danforth's short-tail (Sd). In this mutant, the sk...
Topics
- Animals
- DNA-Binding Proteins
- Gene Expression
- Immunohistochemistry
- Mice
- Mice, Mutant Strains
- Morphogenesis
- Notochord
- Paired Box Transcription Factors
- Phenotype
- Signal Transduction
- Transcription Factors