Article
Genetic interactions suggest that Danforth's short tail (Sd) is a gain-of-function mutation.
Developmental genetics - 1 Jan 1998
Zachgo J, Korn R, Gossler A
Abstract excerpt
Danforth's short tail (Sd) is a semidominant mutation on mouse chromosome 2 that acts cell autonomously in the notochord and leads to its distintegration, and thus causes severe defects in somite patterning and vertebral column development. The molecular nature of the Sd gene and mutation is unkn...
Topics
- Alleles
- Animals
- Embryonic and Fetal Development
- Female
- Gene Expression Regulation, Developmental
- In Situ Hybridization
- Lac Operon
- Male
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Mutation
- Notochord
- Phenotype
- Tail