Article
The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate.
Development (Cambridge, England) - 1 Jul 2002
Amacher Sharon L, Draper Bruce W, Summers Brian R, Kimmel Charles B
Abstract excerpt
T-box genes encode transcriptional regulators that control many aspects of embryonic development. Here, we demonstrate that the mesodermally expressed zebrafish spadetail (spt)/VegT and no tail (ntl)/Brachyury T-box genes are semi-redundantly and cell-autonomously required for formation of all trunk and tail mesoderm. Despite the lack of posterior mesoderm in spt(-);ntl(-) embryos, dorsal-ventral neural tube...
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