Basic Helix-Loop-Helix Proteins Can Act at the E-Box within the Serum Response Element of the c-<i>fos</i>Promoter to Influence Hormone-Induced Promoter Activation in Sertoli Cells

Abstract excerpt

The Sertoli cell is a terminally differentiated testicular cell in the adult required to maintain the process of spermatogenesis. Previously basic helix-loop-helix (bHLH) factors and c-fos have been shown to influence Sertoli cell-differentiated functions. The induction of Sertoli cell differentiation appears to involve the serum response element (SRE) of the c-fos promoter to activate c-fos and intermediate bHLH...

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