Casein kinase II enhances the DNA binding activity of serum response factor.

doi:10.1101/gad.4.6.955

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Article

Casein kinase II enhances the DNA binding activity of serum response factor.

Genes & development - 1 Jun 1990

Manak J R, de Bisschop N, Kris R M, Prywes R

Abstract excerpt

Serum response factor (SRF) is a mammalian transcription factor that binds to the serum response element in the enhancer of the c-fos proto-oncogene and thus may mediate serum-induction of c-fos transcription. We report here that the DNA binding activity of recombinant SRF made in Escherichia coli can be greatly enhanced by incubation of the protein with HeLa cell nuclear extract. The enhancing activity is ATP or...

Topics

Adenosine Triphosphate
Base Sequence
Casein Kinases
Cell Extracts
DNA
DNA-Binding Proteins
Escherichia coli
Guanosine Triphosphate
HeLa Cells
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Phosphorylation

Protein Kinases

Proto-Oncogene Mas

Serum Response Factor

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 2200737
DOI: 10.1101/gad.4.6.955

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2200737-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Casein kinase II enhances the DNA binding activity of serum response factor.PMID 2200737Read ↗

Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties.Semantic proximity Read ↗

Phosphorylation-dependent formation of a quaternary complex at the c-fos SRE.Semantic proximity Read ↗

The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation.Semantic proximity Read ↗

Identification of a protein-binding site in the promoter of the human thymidine kinase gene required for the G1-S-regulated transcription.Semantic proximity Read ↗

Sequences at the 3' side of the c-fos SRE mediate gene expression via an Sob1-dependent, TCF-independent pathway.Semantic proximity Read ↗

In vitro squelching of activated transcription by serum response factor: evidence for a common coactivator used by multiple transcriptional activators.Semantic proximity Read ↗

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Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor.Semantic proximity Read ↗

Regulation of c-Fos gene transcription by stimulus-responsive protein kinases.Semantic proximity Read ↗

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